Exploring neuronal bistability at the depolarization block.

Many neurons display bistability--coexistence of two firing modes such as bursting and tonic spiking or tonic spiking and silence.Bistability has been proposed to endow neurons with richer forms of information processing in general and to be involved in short-term memory in particular strict by allowing a brief signal to elicit long-lasting changes

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Towards pragmatism in climate risk analysis and adaptation

The Asia-Pacific region is extremely vulnerable to climate variability and change.This reflects high ORG CALENDULA exposure to hydroclimatic hazards such as tropical cyclones, floods, droughts, and heatwaves.Rapidly growing cities and low-lying coastal zones/estuaries also face threats from sea level rise and storm surges.However, climate model pro

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Patient-Reported Outcomes of Kinematic vs Mechanical Alignment in Total Knee Arthroplasty: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Background: Total knee arthroplasty (TKA) is an effective treatment method for severe osteoarthritis of the knee.Poor alignment of a knee replacement has been associated with suboptimal clinical results.Traditionally, mechanical alignment (MA) has been considered the gold standard.In light of reports of decreased satisfaction with TKA, a new techni

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